Annotated Bibliography
Cagnacci, A., & Venier, M. (2019). The controversial history of hormone replacement therapy. Medicina, 55(9), 1–15.
The history, advantages, and hazards of hormone replacement therapy (HRT) are all thoroughly covered in the paper by Cagnacci and Venier (2019). This article is helpful for the research proposal because it provides historical context and insights into how HRT’s perception and use have changed over time. These historical contexts and insights could help frame the research hypothesis and inform the study design, comparing the effects of HRT on the quality of life of older men.
Gaibor, C., Zhang, Z., Yang, M., & Haider, I. (2023). Portal vein thrombosis extending to the superior mesenteric and splenic veins secondary to a hypercoagulable state due to prior abdominal surgery, hormonal replacement therapy, and flaxseed consumption. Cureus, 15(3), 1–15.
The case report by Gaibor et al. (2023) examines potential hypercoagulable risk factors that may contribute to the development of acute portal vein thrombosis (PVT). This article sheds light on a previously understudied aspect of hypercoagulability and its implications for the quality of life of this population, which is pertinent to the proposed research hypothesis regarding the potential effects of hormone replacement therapy on the health of older men.
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012). Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocrine Reviews, 33(3), 314–377.
The importance of anabolic hormones in preserving physical function and muscle mass in older men is discussed in the article by Giannoulis et al. (2012). This article is helpful for the study proposal hypothesis because it offers insightful information on the potential advantages of HRT in improving the quality of life for older men by addressing the physiological changes associated with aging and frailty.
Vinson, A. J., Anzalone, A., Schissel, M., Dai, R., French, E. T., Olex, A. L., & Zhang, X. T. (2023). Hormone replacement therapy and COVID-19 outcomes in solid organ transplant recipients compared with the general population. American Journal of Transplantation, 23(7), 1035–1047.
The study by Vinson et al. (2023) examines the relationship between HRT and COVID-19 results in solid organ transplant recipients. The authors associate HRT with a decreased risk of adverse outcomes in older patients. These findings can help guide the research proposal’s hypothesis by outlining potential processes by which HRT might enhance the quality of life for older men compared to those who do not receive it.
Raj, R., Korja, M., Koroknay-Pál, P., & Niemelä, M. (2018). Multiple meningiomas in two male-to-female transsexual patients with hormone replacement therapy: A report of two cases and a brief literature review. Surgical Neurology International, 9, 1–5.
The study by Raj et al. (2018) shows two cases of people who used HRT for an extended period of time and developed several growing meningiomas. This article emphasizes the necessity to weigh potential risks and advantages in older men having hormone replacement therapy. It offers crucial insights into the impact of HRT on health outcomes, making it pertinent to the study proposal hypothesis.
Okpechi, S. C., Fong, J. T., Gill, S. S., Harman, J. C., Nguyen, T. H., Chukwurah, Q. C., & Alahari, S. K. (2021). Global sex disparity of COVID-19: A descriptive review of sex hormones and consideration for the potential therapeutic use of hormone replacement therapy in older adults. Aging and Disease, 12(2), 671–683.
The research by Okpechi et al. (2021) provides a comprehensive analysis of the intricate relationships between sex hormones, immune response modulation, aging, and their potential impact on SARS-CoV-2 infection. The article is a helpful resource for understanding the potential advantages of HRT in older men and its impact on their quality of life, as it provides an insightful understanding of the complex interactions between sex hormones, immune function, aging, and COVID-19.
Samango-Sprouse, C., Brooks, M. R., Counts, D., Hamzik, M. P., Song, S., Powell, S., & Gropman, A. L. (2022). A longitudinal perspective of hormone replacement therapies (HRTs) on neuromotor capabilities in males with 47, XXY (Klinefelter syndrome). Genetics in Medicine, 24(6), 1274–1282.
From infancy to maturity, males with 47,XXY (Klinefelter syndrome) participate in the study by Samango-Sprouse et al. to examine the effects of HRTs on neuromotor abilities. This article is helpful for the proposed study hypothesis, as it discusses the effects of hormone replacement treatment on neuromotor abilities and provides evidence of its beneficial effects on motor function in males with the 47,XXY karyotype.
Ranger, T. A., Burchardt, J., Clift, A. K., Mei, W. X., Coupland, C., San Tan, P., & Hippisley-Cox, J. (2021). Hormone replacement therapy and cancer survival: a longitudinal cohort study: Protocol paper. BMJ Open, 11(8), 1–8.
The article by Ranger et al. (2021) explores the association between the use of HRT following a cancer diagnosis and the risk of cardiovascular disease, cancer-specific mortality, additional cancer diagnoses, and all-cause mortality. This article is relevant to the research proposal hypothesis because it provides information on the effect of HRT on cancer survival and overall mortality in a longitudinal cohort of patients.
Rosenthal, A., Jacoby, T., Israilevich, R., & Moy, R. (2020). The role of bioidentical hormone replacement therapy in anti‐aging medicine: A review of the literature. International Journal of Dermatology, 59(1), 23–29.
The paper by Rosenthal et al. (2020) provides a thorough analysis of the research that supports the use of HRT as a method to delay the aging process of the skin. This article is a valuable source for grasping how HRT might influence the quality of life for older individuals, as it provides a thorough examination of both the benefits and safety aspects of bioidentical hormone replacement therapy.
Yabluchanskiy, A., & Tsitouras, P. D. (2019). Is testosterone replacement therapy in older men effective and safe? Drugs & Aging, 36, 981–989.
The possible advantages and drawbacks of testosterone replacement treatment (TRT) for older men over the age of 60 are examined in the review by Yabluchanskiy and Tsitouras (2019). The review is a valuable tool for analyzing the suggested research hypothesis on the effect of TRT on the quality of life of older men since it offers insightful information on the intricate relationship between testosterone replacement therapy and older men’s health.
Summary
HRT may improve the physical function and quality of life in elderly men, according to studies by Giannoulis et al. (2012) and Okpechi et al. (2021). According to Giannoulis et al., anabolic hormones, such as growth hormone and testosterone, help preserve muscle mass and counteract age-related muscle weakness. Okpechi et al. explore the intricate interactions between sex hormones, immunological response, aging, and COVID-19 results, putting forth the possibility of HRT as a treatment. These studies indicate that HRT has a positive impact on the overall well-being of older men.
Research by Gaibor et al. (2023) and Vinson et al. (2023) reveals potential dangers associated with hormone replacement treatment. In their paper, Gaibor et al. describe a case of portal vein thrombosis that HRT, abdominal surgery, or dietary supplements may have triggered. HRT’s impact on COVID-19 results in organ transplant recipients is investigated by Vinson et al., who find that immunosuppressed people may experience uncertain consequences. These findings draw attention to the hypercoagulable hazards and emphasize the need to balance the benefits of HRT with any potential concerns.
The complex interactions between hormone replacement treatment and health outcomes are highlighted by research by Raj et al. (2018), Samango-Sprouse et al. (2022), and Ranger et al. (2021). According to Raj et al., there may be a connection between the development of meningiomas and exogenous sex hormones from long-term HRT. Samango-Sprouse et al. hypothesize that HRT improves motor function in those with Klinefelter syndrome. Understanding the effects of HRT on overall mortality and cancer survival in older people is made possible by Ranger et al. These studies highlight the numerous effects of HRT on health and quality of life.