The most common characteristic of neurodegenerative disorders includes progressive accumulation of misfolded proteins. These proteins are responsible for triggering damage to synapses, disturbing the network of pathways, facilitating the death of specific neuronal populations, and initiating diseases. The most well-known neurodegenerative disease is Alzheimer’s (AD), the pathology of which includes an accumulation of Aβ that forms amyloid plaques and aggregation of phosphorylated tau to constitute neurofibrillary tangles (NFTs). Dysfunction of synapses, loss of neurons, and dementia that are common to the disease are triggered by Aβ (Cai et al, 2014).
Cai et al (2014), described the epigenetic impact of the plumbum, arsenic, and aluminum to AD. These metals can induce AD, according to the same research. This article outlines the connections between several metals and Alzheimer’s disease, demonstrating their significance in the progression of the disease and offering a direction for future research to create new epigenetic therapies. This article outlines the connections between several metals and Alzheimer’s disease, demonstrating their significance in the progression of the disease and offering a direction for future research to create new epigenetic therapies. Scientists evaluated the effect of developmental exposure on neurodevelopment in order to comprehend the instrument to explore neurodevelopmental disorders, emphasizing the significance of using in vitro neural cell systems to study neurotoxicity. The authors go over recent developments in brain complexity recapitulation utilizing cell culture, including compositional, structural, and functional complexity.
Finally, in the context of clarifying their function in neurodevelopmental diseases, it describes how to mimic developmental exposure and evaluate toxicity using cell culture models. Endocrine disruptors, neurotoxins, inorganic metals, histone changes, and miRNAs are all covered in this special topic, which also uses human, animal, and in vitro studies to relate embryonic development, cancer progression, and neurological illnesses.
References
Cai, M., Zhang, X., He, W., & Zhang, J. (2020). The Involvement of Metals in Alzheimer’s Disease Through Epigenetic Mechanisms. Frontiers in Genetics, 11. Web.
Review: In vitro Cell Platform for Understanding Developmental Toxicity. (2020). Frontiers. Web.