Introduction
The medical field is dynamic, and strange ailments emerge that jeopardize people’s quality of life. A community becomes vulnerable when a new disease transpires, requiring urgent medical intervention. COVID-19 was an example of a medical concern that shook the world’s most developed medical facilities. Medical research is, therefore, crucial to ensure that an antidote to any infirmity is developed in time to save people’s lives. This investigation analyzes the relationship between medical research and clinical trials.
Furthermore, it reiterates the crucial role of clinical trials in advancing medical research. Clinical trials are medical experiments used to detect, prevent, and treat medical conditions. The critical importance of clinical trials lies in understanding the genetic organization of disease and developing remedies to overcome the challenges it causes. The trials may be used to determine a more effective treatment for diseases. The authors anticipate the value added by clinical trials in medical research and the benefits accrued in the field as a result of the tests.
Synthesis of the Research Findings
The ultimate goal of clinical research is to introduce the scientific basis for treating diseases. The critical theory applied in a clinical trial is the Health Belief Model, which provides the primary framework for determining a person’s health status. The model comprises five key models: the perceived severity of a condition, the perceived self-efficacy, perceived cues to action, and the perceived barriers. Understanding the theory enables practitioners to evaluate clinical trials effectively, ensuring they serve the research purpose and achieve better outcomes.
Oxford et al. (2020) inferred that clinical trials are designed to advance the understanding of the disease and chart the way forward in developing a specific treatment. Cook et al. (2019) further reiterated that clinical trials were essential in developing more convenient drugs. Clinical tests have been the key to developing the ARV to create secure and more appropriate medication. Clinical trials are the only sure way to determine the cause and propose a solution for different diseases.
Clinical tests typically precede medical treatment in healthcare facilities. According to Minesh & Chakraborty (2021), clinical trials form the basis for advancing new therapies in the healthcare domain. In search trials, people volunteer to participate in the attempt to develop main treatments. The evaluation and treatment of various medical conditions can be used to determine whether the existing medication is effective or not.
The findings align with those of Gray et al. (2021), who stated that clinical trials are essential for generating new medications and engaging the community. Community engagement ensures that people are aware of the risk factors for various diseases and the measures to overcome healthcare challenges. Del Paggio et al. (2021) analyzed the evolution of clinical trials in American oncology since the 1970s, when the concept was born. The research focused on the oncology department and how randomized clinical trials have been crucial in developing effective treatments. The analysis suggested that better medical outcomes have improved since the development and refinement of clinical trials.
Though Cook et al.’s (2019) analysis suggested that clinical trials are the safest means of determining the antidote for a health condition, Gray et al. (2021) stated that they may endanger people’s lives. Most trials are conducted using human samples, which require multiple analyses to determine the causes of the disease and the suggested treatment outcome.
More randomized trials are directly proportional to efficiency, as increasing the number of samples enhances scientific validity. Therefore, it is essential to ensure that all clinical research is connected to a framework that allows for the experimental testing of hypotheses. In both clinical trials, putative surrogates play a significant role and must be present for better outcomes to be achieved.
Research by Oxford et al. (2020) and Del Paggio et al. (2021) suggests that better results can be achieved when clinical trials are diversified and all measures of the disease are tested. When the trials are conducted across different populations, people are more likely to get better results. In the current situation, each geographical region requires separate trials because various pathogens thrive under different conditions.
Notably, the research conducted and analyzed showed the importance of clinical trials in the medical research domain. Most inferences focused on how technological advancements have impacted the medical field. However, a key point to note is how clinical trials can be improved to enhance the quality of medical research. Since the study’s primary aim is to enhance medical research through improved clinical trials in the management of hypertension, the progression of the disease can only be fully understood through additional studies. Analysis without the samples may lead to inaccurate results and poor medical outcomes.
Means of adjusting clinical trials for better products must be developed. The research by Minesh & Chakraborty (2021), which stated that the samples must be analyzed using statistical means, contradicts the inference by Gray et al. (2021). The latter research noted that the essential element in the trials is to ensure each population has a different test because each has different outcomes. The evident gap in knowledge is the best way to improve clinical trials and achieve more accurate results in the long run.
The treatment of central nervous system disorders is considered to be one of the most challenging medical concerns. However, continuous research has suggested that clinical trials are essential for understanding various ailments related to the CNS and that developing an antidote is feasible (Oxford et al., 2020). The trials enable medical practitioners to understand the pathogens that cause the disease and the possible gene mutation.
Since some trials depend solely on the endpoint, an appropriate standard operating procedure must be established for all trials to ensure consistency and standardization. Furthermore, the clinical trials have undergone numerous evolutions and must be taken into consideration. Regulation is critical in ensuring that clinical trials give the best possible outcomes in the discourse.
Randomized clinical trials are the most advanced versions of clinical trials that are necessary to generate accurate results in research (Del Paggio et al., 2021). The initial step of improving medical research is ensuring that the tests are conducted accurately. Advancing clinical trials is likely to have a ripple effect in medical research.
Critique of the Previous Research Methods
Previous research has highlighted the benefits of clinical trials in the medical research process. However, the employed methodologies had limitations that jeopardized the outcomes. A study by Minesh & Chakraborty (2021) concluded that clinical trials are the essence of improving medical research through developing new medications.
However, the research methodology involved the use of volunteers who were passionate about creating new medicines. Nevertheless, using volunteers can affect their quality of life, as the side effects of the diseases are likely to impact individuals. Only samples would be used to research and test the efficiency before the new medication is rolled out.
Cook et al. (2019) employed statistical research, which could lead to inferences after statistical interpretation. However, the methodology required greater validity, as the sample size needed to be larger. The findings could not be extrapolated to affect other developments. It takes statistical validity and reliability to ensure effective clinical trial outcomes. This research will, therefore, ensure that the trials are reliable, valid, and authentic, thereby adding value to the field of medical research.
Randomized clinical research is considered the most effective method for generating accurate medical outcomes. However, the random sample only represents an adequate number of people and is, therefore, likely to yield results that are not entirely accurate. Del Paggio et al. (2021) traced the evolution of randomized clinical trials and explored ways to improve them, making medical research more efficient.
However, precision in oncology has improved whenever the research sample size was increased to make the results more accurate. The primary challenge in the research methodology was selecting samples that were not aligned with the evolving research on clinical trials. The research gap can, however, be addressed by ensuring that the research sample is increased and reliability is tested before the final results are presented.
Gray et al.’s (2021) research suffered setbacks because of the norms of the people affected by the clinical trial. The methodology challenge can be improved by ensuring people have the correct awareness and organizing tests in tandem with their norms and traditions. Beliefs, norms, and sustainability must be considered when developing clinical trials to ensure they add value to the discourse.
Bidirectional feedback is crucial in ensuring that clinical trials contribute value to medical research. Oxford et al. (2020) investigated the potential methods for obtaining a cure for Alzheimer’s disease through clinical trials. The primary challenge of the methodology was that the animal models used needed to be suitable for determining efficacy in humans. Before a clinical trial, participants must be educated and their expectations managed to achieve effective results.
Conclusion
The clinical trial serves as the basis for developing antidotes and cures to treat various ailments. The evolution of randomized clinical trials has been central to the development of modern medication (Oxford et al., 2020). Clinical trials have played a significant role in the advancement of medicines for hypertension, Alzheimer’s disease, and other serious ailments, such as the COVID-19 pandemic. The critical barriers in clinical trials include unreliability, small sample sizes, and participants’ attitudes and cultural traditions.
Understanding the populations and using a larger model for research is critical to improving the validity of clinical trials (Del Paggio et al., 2021). Furthermore, different regions with varying pathogens require distinct trials. Investigating and improving clinical trials will probably have a ripple effect on healthcare research. The field of medical research can be improved when clinical trials are improved to form the basis of accurate data collection.
References
Cook, J. A., Fergusson, D. A., Ford, I., Gonen, M., Kimmelman, J., Korn, E. L., & Begg, C. B. (2019). There is still a place for significant testing in clinical trials. Clinical Trials, 16(3), 223-224. Web.
Del Paggio, J. C., Berry, J. S., Hopman, W. M., Eisenhauer, E. A., Prasad, V., Gyawali, B., & Booth, C. M. (2021). Evolution of the randomized clinical trial in the era of precision oncology. JAMA Oncology, 7(5), 728-734. Web.
Gray, D. M., Nolan, T. S., Gregory, J., & Joseph, J. J. (2021). Diversity in clinical trials: an opportunity and imperative for community engagement. The Lancet Gastroenterology & Hepatology, 6(8), 605–607. Web.
Minesh, P., & Chakraborty, G. S. (2021). A role of a clinical trial in the management of hypertension and medication of hypertension. Research Journal of Pharmacy and Technology, 14(6), 3215–3222. Web.
Oxford, A. E., Stewart, E. S., & Rohn, T. T. (2020). Clinical trials in Alzheimer’s disease: a hurdle in the path of remedy. International Journal of Alzheimer’s Disease. Web.