Crohn’s disease is an inflammatory disturbance that can affect any part of the digestive tract from the mouth to the rectum. This chronic pathology is constantly progressing, causing irreversible changes in the mucosa. Therefore, new therapy methods are continually being developed and implemented. One of the most effective ones is a capsule wireless endoscopy. The new approach involves swallowing a pill with a tiny camera that transmits an image that identifies the disease (Brazier, 2021). Furthermore, one of the latest procedures is detecting ASCA, a specific serologic marker that confirms a patient has Crohn’s disorder.
In the initial stages, conservative treatment with anti-inflammatory drugs, hormones, and immunosuppressants with a sparing diet is usually used. However, it is now possible to operate extracorporeal hemocorrection methods, which help to remove circulating immune complexes autoantibodies from the bloodstream. This reduces the dosage of hormones while maintaining and even increasing their effectiveness (Brazier, 2021). Moreover, one of the innovative treatment techniques is the transplantation of fecal microbiota. All patients with antibiotic-associated Clostridium difficile colitis experienced remission and restoration of normal microflora after a single procedure. Patients with inflammatory bowel disease against the background of essential therapy had from one to two treatments with a positive effect.
Researchers also found that the interaction between Fn14 receptors and tumor necrosis factor in patients with inflammatory gastrointestinal tract is overexpressed. They concluded that a targeted treatment for Crohn’s disease might suppress Fn14 receptor activity (Brazier, 2021). Moreover, repeated calprotectin measurement in patients in remission is also crucial for eliminating the disease; this procedure helps to detect the outbreak of the disorder early. Transverse visualization methods, including magnetic resonance enterography and ultrasound examination of the intestine, can be utilized for periodic assessment of the impact of therapy on the intestinal wall (Brazier, 2021). Modern high-resolution digital equipment and proper management of patients with suspected inflammatory bowel disease make it possible to diagnose Crohn’s disease even in remission, when external manifestations may not be present. Thus, although there is no single treatment method, new technologies constantly appear to stimulate improvements in therapy plans.
Reference
Brazier, Y. (2021). All you need to know about Crohn’s disease. Medical News Today. Web.