Amoxicillin Allergies in Patients Essay

Exclusively available on Available only on IvyPanda® Made by Human No AI

Amoxicillin is a standard antibiotic often used in primary care settings. It consists of an aminopenicillin, with an extra amino group added to the penicillin, which fights antibiotic resistance (Akhavan et. al., 2020). It may cause difficulties in patients with hypersensitive reactions. The types of reactions determine the severity of the symptoms. Type-I and type-IV are the most important to remember as one can be more dangerous than the other. A type-I reaction activates a histamine release which in turn causes a pruritic rash in mild cases and systemic issues, such as anaphylaxis, in serious circumstances.

While in general it is recommended that skin testing be done prior to drug provocation test in the evaluation of amoxicillin allergy, there is increasing evidence that drug provocation testing could be done in lower risk children without skin testing prior. It is estimated that while 10% or children have an amoxicillin allergy, most patients are able to tolerate the antibiotic after being evaluated (Abrams & Moshe, 2019). Testing remains necessary as allergic reactions to amoxicillin often suggest negative effects on health, but the methods remain debatable.

There have been multiple studies that suggest that lower-risk patients can take drug provocation tests without prior skin testing. In a study, pediatric patients with histories of allergic reactions to amoxicillin were tested with the antibiotic. However, the study continued a 5-day administration to those patients that did not present immediate allergic reactions (Labrosse et.al., 2018). A similar study focused on testing children with history of instant reactions, including anaphylaxis, with skin prick test and additional oral graded exams (Faitelson et.al., 2018). The skin tests did not help the diagnosis of amoxicillin allergies but the history of drug allergies, asthma, and reaction during older age sufficed as predictive elements for actual reactions to the antibiotic.

In a recent study, allergists observed that patients, especially children, with amoxicillin-associated allergic reactions became non-allergic when rechallenged with the antibiotic. They showed symptoms of urticaria, maculopapular exanthem (MPE), and serum sickness-like reaction (SSLR) (Labrosse et. al., 2019). During the re-exposure, there were more patients presenting signs of SSLR than expected. The study provides a space to phenotype patients presenting allergies in relation to amoxicillin during primary care.

References

Abrams, E. M. & Moshe, B. S. (2019). Should testing be initiated prior to amoxicillin challenge in children? Clinical and Experimental Allergy, 49(8), 1060-1066. Web.

Akhavan, B. J., Khanna, N. R. & Vijhani, P. (2020) Amoxicillin. StatPearls Publishing. Web.

Faitelson, Y., Boaz, M. & Dalal, I. (2018). . Journal of Allergy and Clinical Immunology, 6(4), 1363-1367. Web.

Labrosse, R., Barrios, J. L., Picard, M., Begin, P. & Samaan, K. (2019) . Journal of Allergy and Clinical Immunology, 143(2). Web.

Labrosse, R., Paradis, L., Lacombe-Barrios, J., Samaan, K., Graham, F., Paradis, J., Begin, P. & Des Roches, A. (2018). Efficacy and safety of 5-day challenge for the evaluation of nonsevere amoxicillin allergy in children. The Journal of Allergy and Clinical Immunology: In Practice, 6(5), 1673-1680. Web.

More related papers Related Essay Examples
Cite This paper
You're welcome to use this sample in your assignment. Be sure to cite it correctly

Reference

IvyPanda. (2022, August 26). Amoxicillin Allergies in Patients. https://ivypanda.com/essays/amoxicillin-allergies-in-patients/

Work Cited

"Amoxicillin Allergies in Patients." IvyPanda, 26 Aug. 2022, ivypanda.com/essays/amoxicillin-allergies-in-patients/.

References

IvyPanda. (2022) 'Amoxicillin Allergies in Patients'. 26 August.

References

IvyPanda. 2022. "Amoxicillin Allergies in Patients." August 26, 2022. https://ivypanda.com/essays/amoxicillin-allergies-in-patients/.

1. IvyPanda. "Amoxicillin Allergies in Patients." August 26, 2022. https://ivypanda.com/essays/amoxicillin-allergies-in-patients/.


Bibliography


IvyPanda. "Amoxicillin Allergies in Patients." August 26, 2022. https://ivypanda.com/essays/amoxicillin-allergies-in-patients/.

If, for any reason, you believe that this content should not be published on our website, please request its removal.
Updated:
This academic paper example has been carefully picked, checked and refined by our editorial team.
No AI was involved: only quilified experts contributed.
You are free to use it for the following purposes:
  • To find inspiration for your paper and overcome writer’s block
  • As a source of information (ensure proper referencing)
  • As a template for you assignment
Privacy Settings

IvyPanda uses cookies and similar technologies to enhance your experience, enabling functionalities such as:

  • Basic site functions
  • Ensuring secure, safe transactions
  • Secure account login
  • Remembering account, browser, and regional preferences
  • Remembering privacy and security settings
  • Analyzing site traffic and usage
  • Personalized search, content, and recommendations
  • Displaying relevant, targeted ads on and off IvyPanda

Please refer to IvyPanda's Cookies Policy and Privacy Policy for detailed information.

Required Cookies & Technologies
Always active

Certain technologies we use are essential for critical functions such as security and site integrity, account authentication, security and privacy preferences, internal site usage and maintenance data, and ensuring the site operates correctly for browsing and transactions.

Site Customization

Cookies and similar technologies are used to enhance your experience by:

  • Remembering general and regional preferences
  • Personalizing content, search, recommendations, and offers

Some functions, such as personalized recommendations, account preferences, or localization, may not work correctly without these technologies. For more details, please refer to IvyPanda's Cookies Policy.

Personalized Advertising

To enable personalized advertising (such as interest-based ads), we may share your data with our marketing and advertising partners using cookies and other technologies. These partners may have their own information collected about you. Turning off the personalized advertising setting won't stop you from seeing IvyPanda ads, but it may make the ads you see less relevant or more repetitive.

Personalized advertising may be considered a "sale" or "sharing" of the information under California and other state privacy laws, and you may have the right to opt out. Turning off personalized advertising allows you to exercise your right to opt out. Learn more in IvyPanda's Cookies Policy and Privacy Policy.

1 / 1