The patient is presenting the specific symptoms described due to overdose with opiates. Because naloxone, which is an opioid antagonist, made him responsive, it was possible to reverse the effects of opioid overdose, which causes slower breathing and, as a result, respiratory depression (NIH, 2020). A large amount of necrotic tissue in the left hip and forearm probably developed when the patient lost consciousness and fell. Necrosis is defined by cellular death in the lack of oxygen and blood in the tissue caused by the chemicals’ impact. It is also likely that the patient developed Rhabdomyolysis as a result of muscle injury, while high potassium levels cause prolonged PR intervals and peaked T waves.
It is important to note that both environmental variables and genetics contribute to addictions, with the decree of an individual’s risk for substance abuse proportionate to the genetic connection to an addicted relative (McCance & Huether, 2019). The D2 gene subtype responds to the presence of dopamine produced as a result of stimulant (e.g., drugs or alcohol) use, which enables individuals with a more significant amount of the gene in the body to consume harmful substances. The physiologic response to using opioids consists of sedative and analgesic effects, which result in euphoria and a relaxed state. Opioids attach to the parts of nerve cells referred to as opioid receptors, such as mu, delta, and kappa, each of which plays different roles (Dhaliwal & Gupta, 2020). For instance, mu receptors are responsible for the pleasurable effects of opioids and their capacity to relieve pain. Both gender and genetics are important to consider because both are important for defining the nature of addiction as well as identifying the possible responses to the use of opioids.
References
Dhaliwal, A., & Gupta, M. (2020). Physiology, opioid receptor. Web.
McCance, K., & Huether, S. (2019). Pathophysiology: The biological basis for disease in adults and children. Mosby.
NIH. (2020). Opioid overdose reversal with naloxone (Narcan, Evzio). Web.