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The Role of Inflammation in Cancer Essay

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Updated: Jan 16th, 2022

Introduction

Acute inflammation targets to fix harmed tissues and take out undesirable components. Zhang, Zhu, and Li (2017) define inflammation as the insusceptible defensive reaction of a vascular life form that helps in the expulsion of internal and external destructive stimuli and the upkeep of tissue homeostasis. Even though inflammation aims to restore a normal homeostatic condition where it manifests, it emerges as an agent for the growth and dangerous progression of malignant tissues of most cancers.

The first person to associate cancer

Rudolf Ludwig Carl Virchow was the first person to associate cancer and malignant tissue development with inflammation. Virchow recognized inflammation as one amongst other predisposing conditions for malignant tissue development, describing it as an ‘Out of the normal inflammatory hyperplasia’ (Todoric, Antonucci & Karin, 2016). Inflamed cells and inflammatory signals add to the inception and advancement of cancer. Acute inflammation coming about because of disease or tissue damage through an injury can exist before a normal cell involuntarily changes into a malignancy cell. Circumstances of interminable inflammation can elevate genomic unsteadiness prompting DNA harm, oncogene triggering, or hindered capacity of a tumor suppressor (Zhang et al., 2017). From another dimension, malignant tissue growth and development which was previously not related to inflammation can initiate the advancement of an inflammatory microenvironment that supports malignant tissue and cancer cell growth (Zhang et al., 2017). Regardless of whether it is chronic or it arises from a tumor, inflammation and related stimuli inside the tumor microenvironment allow the multiplication and survival of malignant tissues and cancer cells, foster blood and lymphatic vessel development, and help in attack and metastasis.

Because a majority of the cell types linked to cancer-associated inflammation are, in genetic terms, stable and hence are not exposed to the fast rise of drug resistance, targeting inflamed cells is a promising tactic for preventing and treating cancer. Inflammation is the fundamental action mechanism for various risk factors associated with cancerous cells growth like an infection, overweight and obesity, smoking tobacco, alcohol use, exposure to microelements, dysbiosis, and interminable inflammatory ailments, for example, pancreatitis and colitis (Todoric et al., 2016). Considering the extraordinary shared trait of inflammatory changes in various cancer types, averting or reversing inflammation is a significant way to deal with cancer disease control.

References

  1. Todoric, J., Antonucci, L., & Karin, M. (2016). Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prevention Research, 9(12), 895-905. doi: 10.1158/1940-6207.capr-16-0209
  2. Zhang, Q., Zhu, B., & Li, Y. (2017). Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy. Frontiers in Immunology, 8(71), 1-11. doi: 10.3389/fimmu.2017.00071
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1. IvyPanda. "The Role of Inflammation in Cancer." January 16, 2022. https://ivypanda.com/essays/the-role-of-inflammation-in-cancer/.


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IvyPanda. "The Role of Inflammation in Cancer." January 16, 2022. https://ivypanda.com/essays/the-role-of-inflammation-in-cancer/.

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IvyPanda. 2022. "The Role of Inflammation in Cancer." January 16, 2022. https://ivypanda.com/essays/the-role-of-inflammation-in-cancer/.

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IvyPanda. (2022) 'The Role of Inflammation in Cancer'. 16 January.

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