Chemical Structure, Production Sources, and Action Modes
Helicase is recognized as a motor protein of a ring-shaped structure responsible for coupling hydrolysis of nucleoside triphosphate to acid. Furthermore, Helicase participates in the process of DNA modification: recombination, translation, and replication (Soultanas & Bolt, 2018). The proteins are produced in the DNA strand, which allows them to “pull apart the two strands in a DNA double helix” (Garwan, 2016, line 1). Overall, the main task of the enzyme is to employ ATP energy and hydrolysis to ensure mechanical energy by forming unidirectional movement.
Deficiencies-Related Diseases and Their Treatments
As Helicase is strongly related to DNA modification, it is evident that people with a deficiency of this enzyme might suffer from premature aging. However, the improper modifications of DNA strands are likely to increase cancer predisposition, as most UAE residents experience (Sidorova & Monnat Jr, 2018). In other words, people have a higher risk of developing cancers in various parts of the body as DNA is not adequately replicated, repaired, and recombined. Still, according to Julia Sidorova and Raymond Monnat Jr (2018), modern technology has advanced the treatments for helicase deficiency repercussions, and the problem of premature aging is now being cured with antibody drugs. On and whole, it appears challenging to discover medicine for most deficiency-related illnesses as DNA modifications are still not thoroughly studied.
References
Garwan, R. (2016). DNA Helicase. Alverno College. Web.
Sidorova, J. M., & Monnat Jr, R. J. (2018). DNA Helicase Deficiency Disorders.ELS, 1–11. Web.
Soultanas, P., & Bolt, E. (2018). Helicase mechanism of action. SpringerLink. Web.